A walk-off single by Brett Murray in the bottom of the ninth inning gave Creighton a 4-3 victory over Nebraska Tuesday night at TD Ameritrade Park.
It was the Bluejays first win in their last eight meetings with the Huskers, dating back to 2013. CU improved to 21-7, while NU fell to 22-11 on the year.
Creighton hosts South Dakota State Wednesday night.
Nebraska opens a three-game series at Michigan on Friday.